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GemStone™

GemStone
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GemStone Reader
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Installation & activation

Overview

GemStone is a revolutionary new paradigm for analysis of high-dimensional, flow cytometry data. Based on patented Probability State Modeling* technology, GemStone eliminates the problems that have faced flow cytometry analysis for decades, providing a solution that is science-based, data-driven, scalable, and reproducible. It is exceptionally well-suited for automating processes in your lab.

Verity Software House is making an unprecedented effort to get up and running with this new paradigm. Send us an email or give us a call today.

*US Patent Number 7,653,509

Mac OSXMac OSX    WindowsXP SP3, Win 7, Win 8

How does it work?

An additional parameter based on states and probabilities is defined using our patented Probability State Modeling (PSM) technology. Referred to as State Index, this new parameter is used to parametrically correlate all the other parameters in the system.

Why is it better?

Subjective gating and associated errors are eliminated. Population overlaps in multidimensional data are accounted for. Data defined by numerous correlated parameters are presented in simple-to-understand graphics. Multiple samples may be combined into one coherent analysis.

What assays can I use it for?

GemStone is a very versatile application. It is exceptional for analyzing cell progressions, like B cell analysis and T cell activation, and understanding the diseases associated with them. But that's not all it can do with your flow data. GemStone has been used for fetomaternal hemorrhage (FMH), paroxysmal nocturnal hemoglobinuria (PNH), and CD34 stem cell enumeration assays. In these assays, GemStone's ability to identify subsets automatically without the use of gating has proven highly accurate and reproducible.

What cool features does it have?

State vector arrows and animations let you understand your data like never before. Data zooming, a powerful macro language, a batch system with a built-in database, and common parameter mapping are just a few of the many new innovative features.

GemStone's Heatmap ™ graphics allow you to explore rare events and abnormalities that you have never seen before. The Heatmap tool identifies the low-frequency populations in a sample, and highlights the characteristics in all measurement parameters.

TriCom ™ is another innovative tool for understanding abnormal cell populations. With TriCom, you can identify and quantify each phenotype and the degree of abnormality. Focus your attention on the cells you are really interested in - the abnormal cells - with TriCom.

When can I get it?

Right now. Click here to order.

Videos & Examples

GemStone Model Library: download real-world examples of applications with GemStone

Videos and Tutorials: new demos, tips, and tutorials.

Is GemStone 1.0 Right For You?

GemStone is a completely different way to analyze flow cytometry data. It challenges us to think differently about our science. Traditional techniques for identifying populations of cells are pushed to the side in GemStone, replaced by a new set of tools with which most cytometrists have no experience.

The program is in its infancy. We have only begun to explore the vast number of applications for GemStone. One of our primary goals with version 1.0 of the program is to build a library of models that can be used by others. This library will become an important resource for the GemStone community as it develops.

So, is GemStone right for you?

Are you a GemStone Model Builder or a GemStone Analyzer?

Early adopters of GemStone will need to build "models" or to use models that others have built. Version 1.0 of the program does not build models for you. To decide whether GemStone 1.0 is right for you, consider whether you are a Model Builder or a GemStone Analyzer.

    A Model Builder . . .
  • wants to create new models from scratch
  • enjoys "tinkering" with something until it's just right
  • enjoys the challenge of learning a new tool, if it's a better tool for the job
    A GemStone Analyzer . . .
  • wants to analyze data with existing GemStone models
  • likes things that just work, no fussing with settings and adjustments
  • wants to use GemStone for proven applications

If you are a Model Builder type, GemStone 1.0 is a perfect match for you. It's a great toolkit, and you can be involved in creating models that will be used and appreciated by many.

If you are a GemStone Analyzer type, GemStone 1.0 might be for you. If you are collaborating with someone who is a Model Builder type: yes. Your collaborator will create the model and tweak it, and you'll put it to use. However, if there is no model currently available from Verity or others, you might wait until the model becomes available. The support team at Verity Software House can help you find out if a model is available, and in some cases, we may be interested in working with you to build a model for your application!

We expect that as the program evolves, we'll learn ways to simplify or automate the model-building process. When we reach that stage, the differences between Model Builders and GemStone Analyzers will become less important. After all, the goal is to make GemStone the tool that everyone uses for flow cytometry data analysis!

Want to learn more?

We are offering regular training classes for folks who want to become GemStone model builders. These 2-day sessions are a lot of fun and give you an in-depth understanding of how to build models for your data. Contact us for details and scheduling.

We are also updating our GemStone videos on a regular basis to show all kinds of features in the program. We'll add these videos to our online video library as well as YouTube.

Quick Looks

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